Finally, innovation in analytical and nano delivery-technologies and systems-based approaches opens the door to translational drug development and personalized medicine. We are advancing and applying computational and big data methodologies to enhance drug design as well as pharmacological and/or toxicological mode-of-action and disease modelling. In addition to this, we aim to innovate the field through other routes. We also design novel, effective and safe therapeutics, for example small molecule drugs, biologics and stem cell-based therapeutics.
Understanding these mechanisms opens up the possibility of finding drug targets. We apply various imaging and omics approaches to discover and unravel the molecular mechanisms that are at the basis of disease. To remain at the leading edge of our discipline, we focus on four main themes. Our work aims to discover and develop new drugs and related technologies, and we believe the key to achieve this lies in fundamental research. The Leiden Academic Centre for Drug Research (LACDR) is a multidisciplinary and inclusive research institute. With respect to the tools and techniques, these are designed and prepared through advanced synthetic organic chemistry, and our broad expertise in the design of various probes, fluorescent labels and spin labels gives our chemical biology research a unique edge within the Netherlands. What sets our research apart is the nature of the tools and techniques that we aim for, and in our research objectives, which are always connected to health and disease.
We use synthetic biology, artificial systems and advanced imaging to further clarify the biological systems. Our panel of chemical probes includes enzyme inhibitors and receptor ligands, but also the more advanced activity-based probes. The approach to achieve this goal is a fundamental chemical one we use chemical probes to interrogate biological systems. LED3 researchers within the LIC are grouped under Chemical Biology.Ĭhemical biology research at the LIC is aimed at understanding biological processes at the molecular level. The LIC is organized around two major research clusters: Chemical Biology and Energy & Sustainability. Our chemistry researchers take a fundamental approach in finding tailored solutions for complex societal problems in human health and environmental issues. The Leiden Institute of Chemistry (LIC) is where the Leiden chemistry research comes together. Let us briefly introduce the three institutes. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. LED3 is the combined effort of three excellent institutes of Leiden University. Leiden Early Drug Discovery & Development The scientists behind LED3
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